abstract：:Mechanical ventilation with hyperoxia is a necessary treatment for patients with respiratory distress. However, patients on mechanical ventilation have increased susceptibility to infection. Studies including ours have shown that reactive oxygen species (ROS), generated by exposure to prolonged hyperoxia, can cause a ...

journal_title：Journal of immunotoxicology

authors： Phan BD,Entezari M,Lockshin RA,Bartelt DC,Mantell LL

更新日期：2011-01-01 00:00:00

abstract：:The realization, that the immune system can be the target of many chemicals including environmental contaminants and drugs with potentially adverse effects on the host's health, has raised serious concerns within the public and the regulatory agencies. At present, assessment of immunotoxic effects relies on different ...

journal_title：Journal of immunotoxicology

authors： Galbiati V,Mitjans M,Corsini E

更新日期：2010-10-01 00:00:00

abstract：:The intestinal environment is considered to play an important role both in colorectal tumor development and in the evolution and modulation of mucosal immunity. Studies in animals reared in germ-free (GF, without any intestinal microflora) versus conventional (CV, with regular microflora in bowel) conditions can aid i...

journal_title：Journal of immunotoxicology

authors： Vannucci L,Stepankova R,Grobarova V,Kozakova H,Rossmann P,Klimesova K,Benson V,Sima P,Fiserova A,Tlaskalova-Hogenova H

更新日期：2009-12-01 00:00:00

abstract：:Previously, we showed that in utero exposure to mercury induced phenotypic changes in fetal immune cells. Here, we sought to determine whether the effects of in utero exposure on immune cells persisted in the adult. After overnight breeding to DBA/1 males, pregnant BALB/c dams were given either mercuric chloride in dr...

journal_title：Journal of immunotoxicology

authors： Pilones K,Tatum A,Gavalchin J

更新日期：2009-09-01 00:00:00

abstract：:Many environmental toxins have been shown to suppress the immune system across taxa. The foreign red blood cell (RBC) challenge is an important part of a complement of tests used to assess immunocompetence in the laboratory because it can assess an individual's humoral response without impacting its health. This chall...

journal_title：Journal of immunotoxicology

authors： Quinn MJ Jr,McFarland CA,LaFiandra EM,Johnson MS

更新日期：2009-09-01 00:00:00

abstract：:Some organophosphate insecticides have immunomodulating capacities, but it is unknown whether different compounds within this class affect the immune system to the same extent. In this in vitro study, human immortalized T-lymphocytes or bronchial epithelial cells were treated with diazinon or chlorpyrifos in the absen...

journal_title：Journal of immunotoxicology

authors： Oostingh GJ,Wichmann G,Schmittner M,Lehmann I,Duschl A

更新日期：2009-06-01 00:00:00

abstract：:The objective of this study is to investigate the effects of two different yeast-derived beta-glucans on macrophage functionality and blood cholesterol levels in mice. After establishing their ability to act as a strong stimulator of macrophages, we measured the capacities of the glucans to lower blood cholesterol. Ou...

journal_title：Journal of immunotoxicology

authors： Vetvicka V,Vetvickova J

更新日期：2009-03-01 00:00:00

abstract：:In recent years, progress has been made in understanding how peptides presented by MHC Class I molecules were generated, in particular which proteases are involved in this process and how intracellular pathways influence antigen presentation in professional antigen-presenting cells and various types of tumor cells. Th...

journal_title：Journal of immunotoxicology

authors： Seliger B

更新日期：2008-10-01 00:00:00

abstract：:That benzo alpha)pyrene (Balpha P) decreases both humoral and cell-mediated immunity, and leads to increases in progeny tumor development after in utero insult, suggests that T- and B-lymphocytes are made defective in exposed offspring. In the study here, C3H mice were injected once with Balpha P (150 microg/g BW) at ...

journal_title：Journal of immunotoxicology

authors： Urso P,Wirsiy YG,Zhang W,Moolenaar-Wirsiy PJ

更新日期：2008-07-01 00:00:00

abstract：:Vanadium, an important air pollutant derived from fuel product combustion, aggravates respiratory diseases and impairs cardiovascular function. In contrast, its effects on immune response are conflicting. The aim of our work was to determine if spleens of vanadium-exposed CD1 mice showed histological lesions that migh...

journal_title：Journal of immunotoxicology

authors： Pinon-Zarate G,Rodriguez-Lara V,Rojas-Lemus M,Martinez-Pedraza M,Gonzalez-Villalva A,Mussali-Galante P,Fortoul TI,Barquet A,Masso F,Montano LF

更新日期：2008-04-01 00:00:00

abstract：:Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring inhibitor of the pro-inflammatory interleukin-1-mediated activation of the interleukin-1 receptor (IL-1R). Although wild-type IL-1Ra is used for treatment of inflammatory diseases, its effect is moderate and/or short-lived. The objective of this study...

journal_title：Journal of immunotoxicology

authors： Dahlén E,Barchan K,Herrlander D,Höjman P,Karlsson M,Ljung L,Andersson M,Bäckman E,Hager AC,Walse B,Joosten L,van den Berg W

更新日期：2008-04-01 00:00:00

abstract：:Workers exposed to benzene frequently suffer from toxicities of the bone marrow as well as the central nervous, immune, and reproductive systems. This toxicity most likely is a result of the oxidative metabolism of benzene to reactive products. As green tea possesses antioxidant effects, the objective of this study wa...

journal_title：Journal of immunotoxicology

authors： Emara AM,El-Bahrawy H

更新日期：2008-01-01 00:00:00

abstract：:Here we sought to determine whether prenatal exposure to subtoxic levels of inorganic mercury induced modulations in the fetal immune repertoire. After overnight breeding of female BALB/c and male DBA/1 mice, pregnant females were exposed to 10 mg/l mercuric chloride in drinking water. DBF(1) pups were examined at day...

journal_title：Journal of immunotoxicology

authors： Pilones K,Lai ZW,Gavalchin J

更新日期：2007-10-01 00:00:00

abstract：:Cardiac allografts induce host immune responses that lead to endomyocardial tissue injury and progressive graft dysfunction. Inflammatory cell infiltration and myocyte damage characterize acute cellular rejection (ACR) that presents episodically in either a subclinical or symptom-associated manner. Sampling of the end...

journal_title：Journal of immunotoxicology

authors： Fang KC

更新日期：2007-07-01 00:00:00

abstract：:Pulmonary infections have been reported to be increased in welders. Previous animal studies have indicated that manual metal arc, stainless steel welding fume (MMA-SS) increased susceptibility to lung infections. MMA-SS is composed of a complex of metals (e.g., iron, chromium, nickel). The objective was to determine w...

journal_title：Journal of immunotoxicology

authors： Antonini JM,Roberts JR

更新日期：2007-04-01 00:00:00

abstract：:Toxicological testing of compounds often is conducted at the maximum tolerated dose to identify potential target organs. Toxicities observed at these high doses may result in decreased body weight gain, food consumption and activity. These clinical signs are often associated with a generalized stress response. It has ...

journal_title：Journal of immunotoxicology

authors： Pruett S,Hebert P,Lapointe JM,Reagan W,Lawton M,Kawabata TT

更新日期：2007-01-01 00:00:00

abstract：:Among the different phenotypic changes induced by contact sensitizers in dendritic cells and myeloid cell lines, CD86 appears to be a consensus marker, since constantly described as systematically up-regulated. To evaluate the robustness of this marker, interference of cytotoxicity on CD86 expression was investigated ...

journal_title：Journal of immunotoxicology

authors： Ade N,Martinozzi-Teissier S,Pallardy M,Rousset F

更新日期：2006-12-01 00:00:00

abstract：:Indirubin-3-monoxime is an aryl hydrocarbon receptor (AhR)-binding, idole-derived compound known to be a potent inducer of CYP1A1, at least in hepatic cell lines. To date, very little is known about the effects of indirubin-3-monoxime on cells relevant to the immune system. We treated human U937 histiocytic lymphoma c...

journal_title：Journal of immunotoxicology

authors： Springs AE,Rice CD

更新日期：2006-01-01 00:00:00

abstract：:Hexachlorobenzene (HCB) is an environmental pollutant that induces adverse immune effects in humans and rats. Brown Norway rats (BN) appear to be very susceptible to HCB-induced immune effects. Oral exposure causes inflammatory skin and lung lesions, enlarged spleen and lymph nodes (LN) and elevated humoral responses....

journal_title：Journal of immunotoxicology

authors： Ezendam J,Vos JG,Pieters R

更新日期：2005-07-01 00:00:00

abstract：:An anonymous survey of pharmaceutical industry practices for immunotoxicology evaluation was conducted. This was in support of the development of the guideline on the preclinical evaluation of unintended modulation of the immune system for the International Conference on Harmonization of Technical Requirements for Reg...

journal_title：Journal of immunotoxicology

authors： Weaver JL,Tsutsui N,Hisada S,Vidal JM,Spanhaak S,Sawada J,Hastings KL,van der Laan JW,van Loveren H,Kawabata TT,Sims J,Durham SK,Fueki O,Matula TI,Kusunoki H,Ulrich P,Nakamura K

更新日期：2005-07-01 00:00:00

abstract：:Use of enzymes in cosmetic products is novel and the safety of these products is not well understood. The safety of a prototype enzyme-containing body moisturizer lotion was tested via measures of skin compatibility and potential to induce protease-specific IgE antibody in a clinical study. Female, atopic subjects (n ...

journal_title：Journal of immunotoxicology

authors： Sarlo K,Adamson GM,Hollis VL,Innis JD,Babcock LS,Kirchner DB

更新日期：2004-04-01 00:00:00